Pyrrho of Ellis brought up the notion of the epoche, or the problem of the criterion: not simply the regression unto "First Cause" but what = Truth. He and later contemplators, like Descartes, noted that even atom-counting (or bean-counting, back in the day) was not 100% proof-positive, e.g. for the "what iffers" like Hume. So, if you're a what-iffer on the opposite side from Hume, then there could be a Big Causality. A female scientist at Harvard shows more common sense: Dr. Lisa Randall, a physicist of the first order, says, paraphrased, "Why would a higher species want to simulate us?" Thus, one may note the solipsism and even fear of a negative what-iffer, and compare it with the similar general condition of solipsism of the science fiction engineer/what iffers who are into building things. "Why would a Level III civilization want to simulate us?" Very perceptive, almost like the difference, writ large, between action figures building a fort, and a proper tea party with dolls.
The question of the simulation is a philosophic issue: https://en.wikipedia.org/wiki/Simulation_hypothesis and
Plato's Cave allegory and even such as
https://plato.stanford.edu/entries/baudrillard/